Diversity And Dialogue In Immunity To Helminths Pdf

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diversity and dialogue in immunity to helminths pdf

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Modulation of Specific and Allergy-Related Immune Responses by Helminths

New Search. E-Journal Titles. Database Titles. Interlibrary Loan. Search Everything. Course Reserves. Advanced Search. Immunology, , Vol. Peer Reviewed.

Download PDF. View Online Access Options. View Issue Contents in BrowZine. Export RIS. Online Access Options. Full text availability. Most recent 1 year s not available. Nature Available from volume: 1 issue: 1. Search it in Google Scholar. Resource Type. Diversity and dialogue in immunity to helminths. Maizels, Rick M. Allen, Judith E.

Nature reviews. ISSN: EISSN: DOI: PMID: Antigenic Variation. Cytokines - metabolism. Immunity - immunology.

Helminths - physiology. Host-Parasite Interactions - immunology. Th2 Cells - immunology. Th2 Cells - metabolism. Helminthiasis - parasitology. Helminths - immunology. Models, Immunological. Helminthiasis - immunology. Genetic Variation - immunology. Immunity - genetics.

Cytokines - immunology. Immune response. Worms, Intestinal and parasitic. Genetic aspects. Health aspects. Biological diversity. Index Medicus. England: Nature Publishing Group. Gale Academic OneFile. Gale OneFile: Health and Medicine. Nature Reviews. Academic Search Premier. Nature Journals Online. The constant pressure of helminth infections has been a powerful force in shaping not only how immunity is initiated and maintained, but also how the body self-regulates and controls untoward immune responses to minimize overall harm.

In this Review, we discuss recent advances in defining the immune cell types and molecules that are mobilized in response to helminth infection. Finally, we more broadly consider how these immunological players are blended and regulated in order to accommodate persistent infection or to mount a vigorous protective response and achieve sterile immunity.

The vertebrate immune system has evolved in concert with a broad range of infectious agents, including ubiquitous helminth worm parasites. Staff View. Find sources citing this or sources cited in this.

Immunomodulation and Immune Escape Strategies of Gastrointestinal Helminths and Schistosomes

Helminths are master regulators of host immune responses utilising complex mechanisms to dampen host protective Th2-type responses and favour long-term persistence. Such evasion mechanisms ensure mutual survival of both the parasite and the host. In this paper, we present recent findings on the cells that are targeted by helminths and the molecules and mechanisms that are induced during infection. We discuss the impact of these factors on the host response as well as their effect in preventing the development of aberrant allergic inflammation. We also examine recent findings on helminth-derived molecules that can be used as tools to pinpoint the underlying mechanisms of immune regulation or to determine new anti-inflammatory therapeutics.


helminths induce an entirely distinct immune response profile from Diversity and dialogue in immunity ALL LINKS ARE ACTIVE IN THE ONLINE PDF.


2016, Number 1

Helminth parasites are complex metazoans that belong to different taxonomic families but that collectively share the capacity to downregulate the host immune response directed toward themselves parasite-specific immunoregulation. Helminth-induced immunoregulation occurs through the induction of regulatory T cells or Th2-type cells or both. However, secreted or excreted parasite metabolites, proteins, or extracellular vesicles or a combination of these may also directly induce signaling pathways in host cells.

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Diversity and dialogue in immunity to helminths

Skip to search form Skip to main content You are currently offline. Some features of the site may not work correctly. DOI: Allen and Rick M. Allen , Rick M.

Publications - A, Allen, J. Parasitology : Hewitson, J. Journal of Immunology Hewitson, J. J, Grainger, J.

The vertebrate immune system has evolved in concert with a broad range of infectious agents, including ubiquitous helminth worm parasites. The constant pressure of helminth infections has been a powerful force in shaping not only how immunity is initiated and maintained, but also how the body self-regulates and controls untoward immune responses to minimize overall harm. In this Review, we discuss recent advances in defining the immune cell types and molecules that are mobilized in response to helminth infection. Finally, we more broadly consider how these immunological players are blended and regulated in order to accommodate persistent infection or to mount a vigorous protective response and achieve sterile immunity. Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms helminths and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host.


Here, Judith Allen and Rick Maizels discuss how these responses are generated and provide protective immunity during helminth infection.


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Parasitic worms helminths developed various immunoregulatory mechanisms to counteract the immune system of their host. The increasing identification and characterization of helminth-derived factors with strong immune modulatory activity provides novel insights into immune escape strategies of helminths. Such factors might be good targets to enhance anti-helminthic immune responses. In addition, immunosuppressive helminth-derived factors could be useful to develop new therapeutic strategies for treatment of chronic inflammatory conditions. This review will take an in depth look at the effects of immunomodulatory molecules produced by different helminths with a focus on schistosomes and mouse models of hookworm infections. Helminths are the most commonly found group of parasites in humans. Especially in regions with poor hygiene standards and insufficient access to medical care, helminths are spread easily and, in some cases, cause severe damage to the infected subjects.

Maizels Lab Publications 2011-2014 (227-281)

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