Exercise And Type 1 Diabetes Pdf

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The management of type 1 diabetes mellitus T1DM is based on three pillars: insulin therapy, nutrition, and regular practice of physical activity. Physical exercises are associated with metabolic demands that depend on the individual's energy stores and level of physical conditioning, and vary according to environmental conditions and intensity, duration, and type of exercise.

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Exercise management in type 1 diabetes: a consensus statement.

The management of type 1 diabetes mellitus T1DM is based on three pillars: insulin therapy, nutrition, and regular practice of physical activity. Physical exercises are associated with metabolic demands that depend on the individual's energy stores and level of physical conditioning, and vary according to environmental conditions and intensity, duration, and type of exercise.

All these factors, added to eventual distress with competitions, exert influence on glucose metabolism. The athletic career of diabetic individuals is often hindered by a risk of hypoglycemia during and after the exercise, frequent hyperglycemia before, during, and after certain physical activities, occurrence of ketoacidosis, and presence of chronic microvascular and macrovascular complications. Aerobic exercises reduce the levels of blood glucose while anaerobic exercise may promote transient hyperglycemia.

Although diabetic individuals may achieve excellence in sport, their physical performance should be maximized by strict blood glucose control, adequate modifications in insulin dose on the day of the exercise, and appropriate nutritional intake. This review discusses the impact of physical exercise on glucose metabolism, as well as nutritional considerations and strategies appropriate to the practice of physical exercises by patients with T1DM. Treatment of type 1 diabetes mellitus T1DM is comprised of medications, proper nutrition, and regular physical activity 1.

Due to its therapeutic benefits, physical exercise is widely recommended for diabetic patients. Many diabetics turn the regular practice of physical activity into a routine of training that ranges from participation in recreational activities, games, or school competitions, to even Olympic careers.

Athletic activities are considered safe for patients with T1DM, provided that the athletes and the multidisciplinary team caring for them pay attention during the exercise to the particularities and requirements of the disease 2. However, during training and competition, athletes with T1DM face some challenges and are required to deal with physiological demands associated with exercising at different intensities, such as special nutritional requirements, changes in meal schedule, and physical distress associated with competition 3.

In addition to these factors, athletes with T1DM face a substantial risk of hypoglycemia during and after exercising. There are also frequent reports of hyperglycemia before, during, and after some types of exercises, which add to the risk of ketoacidosis, and chronic microvascular and macrovascular complications may hinder the career of athletes with T1DM 4 , 5 , 6. Despite the limited number of well-controlled studies supporting effective treatment plans for diabetic patients performing regular physical training, this review aims to discuss the current evidence regarding the impact of physical exercise on the dynamics of blood glucose control, in addition to nutritional considerations and appropriate strategies for the practice of physical exercise by patients with T1DM.

A routine of regular physical exercises may bring several health benefits to diabetic patients, including a decrease in cardiovascular risk, maintenance of body weight, reduction in blood pressure, and improvements in blood glucose control and well-being 6 , 7 , 8.

Guidelines of the American Diabetes Association 2 and the American College of Sports Medicine 9 recommend that diabetic individuals are prescribed individualized exercise regimens with well-defined objectives. These recommendations include participation in exercise sessions of moderate intensity for at least minutes a week in the absence of contraindications such as diabetic neuropathy, proliferative diabetic retinopathy, uncontrolled hypertension, and metabolic ketoacidosis The practice of physical exercise is associated with metabolic demands that depend on the exercise type aerobic or anaerobic, according to the predominant metabolic energy source required during exercise , form continuous or intermittent, according to the interruption of the sets of exercise , intensity very light, light, moderate, vigorous, near-maximal to maximal and duration short, moderate, long 11 , These demands are also determined by ambient conditions cold, heat, humidity, time of the day, altitude , and the individual's energy stores and level of physical fitness 13 , The degree of effort exerted during physical activity may be indirectly measured by the level of oxygen consumption.

The maximum amount of oxygen VO 2 m ax utilized by the body at each minute during the exercise measures the maximum aerobic effort capacity. However, low effort levels may be anaerobic at high altitudes and when performed by individuals who are sedentary, anemic, or with cardiac and pulmonary disease The transition from rest to moderate exercise is characterized by activation of sympathetic and hormonal systems that stimulate the use of the glucose stored in the muscle and liver, and the release of free fatty acids by the adipose tissue These rates lead to a fast decrease in serum glucose concentration due to an impairment in the glucagon counter-regulatory response.

In some patients with T1DM, glucagon response to reduced blood glucose levels 23 may be impaired after a few years, although there have been reports of an appropriate release of glucagon during exercise in these patients In any case, even with a satisfactory glucagon and epinephrine response to physical exercise in T1DM, elevated levels of exogenous insulin may directly or indirectly inhibit glucagon secretion due to its antagonist effect, and reduce lipolysis and proteolysis 25 - Following this line of thought, the high rate of carbohydrate oxidation during physical exercise in T1DM could be one of the factors leading to a decrease in blood glucose levels.

Several factors affect the levels of plasma glucose in diabetic athletes, and hypoglycemia may manifest immediately after the exercise or hours later. During or soon after moderate intensity exercises, it is possible that an energy balance inadequate to the demand of the exercise, added to an excessive amount of insulin administered to the subcutaneous in areas involved in the exercise, increases the rates of insulin absorption promoting hypoglycemia 31 , Physical exercise can also amplify the effects of insulin because it facilitates the transport of glucose through the cell membrane and increases muscle glucose absorption by up to 20 times.

These effects promoted by physical exercises benefit the glycemic control both in nondiabetic and diabetic individuals, but in the latter they may lead to late hypoglycemia. Studies report that the two main defenses against hypoglycemia are impaired in T1DM patients as these individuals are unable to decrease the levels of circulating insulin and have impaired glucagon response 23 , 25 , Thus, only epinephrine remains a front line counter-regulatory defense against hypoglycemia in T1DM patients.

Even then, the epinephrine response may be less robust and occur only at low blood glucose levels 34 , Due to that, signs and symptoms of hypoglycemia related to autonomic regulation are impaired in these individuals 36 , Signs and symptoms of hypoglycemia due to adrenergic sympathomimetic stimulation include hunger, tremor, anxiety, tachycardia, and palpitation, whereas those due to neuroglycopenia reduced availability of glucose to support cerebral functions include weakness, fatigue, loss of coordination, disjointed speech, and blurred vision It has been postulated that repeated episodes of hypoglycemia reduce the sensitivity to epinephrine, a phenomenon known as hypoglycemia-associated autonomic failure HAAF The authors observed that these episodes of hypoglycemia reduced the response of the counter-regulatory hormones to a new episode of hypoglycemia in the following exercise session.

Hypoglycemia associated with physical exercise can occur hours after the exercise and may occasionally occur in the evening. Additionally, it has been speculated that an increased cortisol release during prolonged physical exercise may contribute to the development of HAAF 42 , although a reduction in cortisol production has not been shown to improve HAAF after exercise.

In contrast, the absence of hypoglycemia for a few weeks may improve the response to epinephrine by increasing the glycemic threshold for the release of counter-regulatory hormones and exacerbate the signs of hypoglycemia It is important to emphasize that sexual dimorphism seems to substantially influence the response of the counter-regulatory hormones to blood glucose levels. During prolonged exercise, women with T1DM present lower levels of epinephrine, norepinephrine, and growth hormone compared with men.

Despite the low response to catecholamines, lipolytic rates have been described as significantly higher in women than men, suggesting that women have a greater beta-adrenergic sensitivity In a way, the fact that women preserve fat oxidation after exercise-induced hypoglycemia confers a protective benefit, and therefore, lower susceptibility to HAAF.

Hypoglycemia is a common and dreaded complication in athletes with T1DM 42 , The best approach to hypoglycemia associated with exercise is to prevent its occurrence. Athletes with T1DM, and those professionals and friends close to them, must be alert to signs and symptoms of hypoglycemia, which should be treated with ingestion of carbohydrates, preferably with glucose.

If the patient is unconscious and unable to ingest food or fluids orally, they must receive a glucagon injection However, physically active individuals with well-controlled T1DM often have an aerobic capacity within the normal age range 46 , Several cardiovascular, metabolic, and muscular impairments in patients with T1DM help explain the decrease in aerobic and anaerobic performances 23 , 36 , 46 , In a recent study, Rissanen, Tikkanen, Koponen, Aho, Peltonen 49 observed that physically active adults with T1DM present a lower cardiovascular response to exercise at peak working rate, in addition to a lower systolic volume, systemic vascular resistance, VO 2 m ax, and blood flow.

These observations reflect central and peripheral limitations in diabetic individuals when compared with nondiabetic ones. In contrast, studies have not found significant differences in aerobic capacity in diabetic adults who are long distance runners or very active when compared with nondiabetics 50 , Therefore, it is still uncertain whether the reduced aerobic capacity in T1DM is due to poor muscular oxygenation or to the amount of muscle capillaries Anaerobic exercises, such as sprints, short-distance races, or even collective sports, generally do not cause significant changes in blood glucose, but when this occurs it is often associated with an increase in blood glucose levels in individuals with T1DM due to an increase in catecholamines and production of lactate 53 , The increase in levels of lactate and catecholamines during anaerobic exercise is known to reduce the consumption of glucose and free fatty acids by the muscle 55 and increase the hepatic production of glucose via blood lactate Exercise-induced hyperglycemia may last for hours after the end of an activity and somehow interfere with the glycemic control and later performance in sport Studies suggest that high-intensity intermittent exercises attenuate the decrease in blood glucose levels that are frequently observed in moderate intensity exercises 4 , 57 - Harmer et al.

Such an increase may be related to plasma levels of lactate, as lactate may induce insulin resistance during high-intensity exercise 27 , This phenomenon explains the increase in blood glucose levels even in the presence of increased insulin levels.

The changes in blood glucose levels observed after high-intensity anaerobic training suggest that this type of training is associated with better insulin clearance, reduced catecholamine stimulation, and increased cellular content of glucose transporter type 4 GLUT4 The transport of blood glucose to the myocyte is mainly performed by GLUT4.

In response to insulin post-exercise or muscle contraction and stimulated by the increase in calcium concentration during exercise, GLUT4 translocates both to the cellular membrane and to the T-tubules Interestingly, studies indicate that only 10 seconds of high-intensity aerobic exercise are required to prevent post-exercise hypoglycemia in patients with T1DM 57 , Similarly, the practice of exercising with weights before aerobic exercises attenuates the decrease in blood glucose Another study attempted to mimic sports games using high-intensity stimuli with 4-second shots followed by 2 minutes of active recovery for 20 minutes.

The authors observed that the association of anaerobic and aerobic exercises did not increase the risk of hypoglycemia 4. Thus, the increase in catecholamines and growth hormone levels during high-intensity exercise may prevent hypoglycemia, as after exercise these hormones increase the hepatic production of glucose and inhibit the uptake of glucose in response to insulin stimulation 56 , Although most studies related to the prescribing of anaerobic exercises to T1DM patients have shown positive results regarding the reduction of cases of hypoglycemia associated with acute exercise, the risk may increase hours later Still, more studies are required to provide a scientific basis for the development of guidelines in this setting.

This approach is fundamental to an ideal glycemic control, maintenance of muscle mass, and storage of hepatic and muscular glycogen, optimizing the exercise performance, reducing fatigue, and preventing complications 3. Before performing exercises, T1DM patients should follow a diet based on the following recommendations:.

This recommendation has proven effective in improving physical performance Although patients with T1DM should ingest g of carbohydrates per meal, diabetic patients undergoing training are required to increase their glycogen stores before competitions and athletic activities by increasing the amount of carbohydrates in their meals, monitoring the blood glucose levels, and if necessary, adjusting the dose of insulin accordingly B Ingestion of an additional amount of 1g of carbohydrate per kg of weight is recommended 1 hour before the exercise.

Preference should be given to low-fat food or fluids C If the exercise lasts for less than 45 minutes, a snack with 15g of carbohydrates ingested minutes before the activity has been reported to be sufficient During physical exercises lasting more than 45 minutes, or even after their end, strategies may be used to maintain carbohydrate oxidation and prevent a reduction in glycogen stores Table 1.

As for hydration, the body may eliminate up to 2. During rest, an individual weighing 70 kg produces 60W of heat, whereas they may produce up to 1kW of heat during intense exercise. To counterbalance the production of heat, the body must produce 1. Thus, to prevent the complications associated with dehydration during physical activities, individuals with T1DM must ingest fluids before, during, and after the exercise. Adequate hydration helps control the body temperature and reduce the overload to the cardiovascular system.

Ingestion of water and isotonic drinks is, therefore, a very important strategy 3 Table 2. Due to biological individualities, metabolic responses to physical training, and environmental variations in temperature, trainers, nutritionists, and physiologists must guide the diabetic patients to determine the best strategy for fluid ingestion and adjustment of carbohydrate content in the diet for adequate hydration and maintenance of normal blood glucose levels.

As insulin has been used illicitly by some athletes especially weightlifters and fighters , it has been listed as a banned substance since Any athlete with T1DM who wants to compete in national or international sports events following international antidoping regulations, is required to have an appropriate documentation provided by a physician about the diagnosis and treatment of the disease In addition to determining the levels of capillary blood glucose as part of the routine in T1DM, glucose levels should also be determined hours and, again, moments before the exercise, so that the glucose trend can be determined and appropriate procedures adopted.

If the glucose levels show a trend toward a decrease values that are lower just moments before the exercise than 2 hours before , carbohydrates may be ingested as a preventive strategy.

In contrast, if the trend points toward an increase a higher glucose level before the beginning of the exercise this strategy may not be necessary In addition to measuring the glucose levels before the exercise, they should also be monitored at the end of the exercise and hours later. In this situation, if the level is too low, the patient should ingest carbohydrates to reduce the risk of hypoglycemia.

In the case of anaerobic exercises in which hyperglycemia may occur due to the intensity of the exercise, insulin adjustments should be avoided or conducted in small doses Another aspect to be observed is the possibility that the athlete may be using anabolic agents, as these agents may induce or worsen hyperglycemia. Regarding the type of insulin, the absorption of mealtime and basal insulin can change with exercise.

In the case of NPH insulin, the absorption doubles with increased temperature at the injection site.

Exercise management in type 1 diabetes: a consensus statement.

Type 1 diabetes is a challenging condition to manage since it includes many facets such as treatment with insulin, technical devices, physiological and behavioral factors. Regular exercise is a cornerstone in diabetes treatment, but management of different forms of physical activity could be difficult for Regular exercise is a cornerstone in diabetes treatment, but management of different forms of physical activity could be difficult for both the individual with type 1 diabetes as well as the health-care provider. People with type 1 diabetes tend to be as physically inactive as the general population, where we see a large percentage of individuals not maintaining a healthy body composition nor achieving the minimum recommended amount of moderate to vigorous aerobic activity per week. Regular exercise can improve both health and wellbeing of individuals with type 1 diabetes, and can help them to achieve their targets for lipid, body mass, and fitness. However, improvements in glycemic control is not forgiven when exercise is added to insulin treatment. There are also several additional barriers to exercise, including fear of hypoglycemia, loss of glycemic control, and inadequate knowledge around exercise management that could be a barrier to glucose control.

Diabetes and Mental Health. Financial Resources. The pediatric diabetes specialists at American Family Children's Hospital present these resources for patients and families with Type 1 diabetes. Type 1 Diabetes View all Transition Programs. Type 1 Diabetes. More Diabetes Technology Information.

Regular exercise is important for health, fitness and longevity in people living with type 1 diabetes, and many individuals seek to train and compete while living with the condition. Muscle, liver and glycogen metabolism can be normal in athletes with diabetes with good overall glucose management, and exercise performance can be facilitated by modifications to insulin dose and nutrition. However, maintaining normal glucose levels during training, travel and competition can be a major challenge for athletes living with type 1 diabetes. Some athletes have low-to-moderate levels of carbohydrate intake during training and rest days but tend to benefit, from both a glucose and performance perspective, from high rates of carbohydrate feeding during long-distance events. This review highlights the unique metabolic responses to various types of exercise in athletes living with type 1 diabetes.

Physical Activity and Type 1 Diabetes

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Сквозь строй не позволял мне загрузить этот файл, поэтому я обошел фильтры.  - Глаза коммандера, сузившись, пристально смотрели на Чатрукьяна.  - Ну, что еще - до того как вы отправитесь домой. В одно мгновение Сьюзан все стало ясно. Когда Стратмор загрузил взятый из Интернета алгоритм закодированной Цифровой крепости и попытался прогнать его через ТРАНСТЕКСТ, цепная мутация наткнулась на фильтры системы Сквозь строй.

 Там темно как в преисподней! - закричала. Джабба вздохнул и положил фонарик рядом с .

 - Северная Дакота - это Хейл. Интересно, какие он строит планы. Обнародует ли ключ.

 Если только Стратмор не придумал что-то особенное и не обошел мои фильтры. Повисла тягостная тишина. Когда Мидж заговорила, ее голос был мрачным: - Стратмор мог обойти фильтры.

Бедлам. Так он и. Очередь из десяти человек, толкотня и крик. Испания не славится эффективностью бюрократического аппарата, и Беккер понял, что ему придется простоять здесь всю ночь, чтобы получить информацию о канадце. За конторкой сидела только одна секретарша, норовившая избавиться от назойливых пациентов.

Почему-то ему казалось, что этот филологический ребус Сьюзан не обрадует. - Хочу тебя обрадовать. Когда я летел домой, - сказал он, желая переменить тему, - я позвонил президенту университета. Сьюзан радостно встрепенулась. - Скажи, что ты ушел с поста декана.

Но одно не давало Фонтейну покоя - то, что Стратмор решил прибегнуть к услугам Халохота. Тот, конечно, был мастером своего дела, но наемник остается наемником. Можно ли ему доверять.

Как они смогут ему противостоять. Эти аргументы она слышала уже много. Гипотетическое будущее правительство служило главным аргументом Фонда электронных границ. - Стратмора надо остановить! - кричал Хейл.

Меган с силой толкнула стенку секции, но та не поддавалась.

Сначала она едва заметно вздрогнула, словно от озноба, и тут же ее захлестнула волна отчаяния. Приоткрыв дрожащие губы, она попыталась что-то сказать, но слов не последовало. Не спуская со Стратмора ледяного взгляда, Сьюзан сделала шаг вперед и протянула к нему руку с зажатым в ней предметом.

 У нас ничего такого не случалось. - Вот.  - Она едва заметно подмигнула.  - В этом все и. - Мидж… - Доброй ночи, Чед.

 Немного? - Глаза Бринкерхоффа сузились.  - У Стратмора стол ломится от заказов. Вряд ли он позволил бы ТРАНСТЕКСТУ простаивать целый уик-энд. - Хорошо, хорошо.

 Этот червь, - начал он, - не обычный переродившийся цикл. Это избирательный цикл. Иными словами, это червь со своими пристрастиями.

Дэвид смотрел на нее и улыбался. - Ну и что ты скажешь, моя красавица. Выйдешь за меня замуж. Лежа в кровати с балдахином, она смотрела на него и знала, что ей нужен именно .

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Physical Activity and Type 1 Diabetes


  1. Thomas A. 17.04.2021 at 03:00

    PDF | The management of type 1 diabetes mellitus (T1DM) is based on three pillars: insulin therapy, nutrition, and regular practice of physical.

  2. Maxtpilave 18.04.2021 at 15:02

    Type 1 diabetes is a disease in which the body does not make enough insulin to control blood sugar levels.

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