Application Of Nanotechnology In Cancer Therapy And Imaging Pdf
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- Nanoparticles in Cancer Therapy: Novel Concepts, Mechanisms and Applications
- Nanotechnology in Cancer Drug Delivery and Selective Targeting
- Nanotechnology Applications for Cancer Chemotherapy
- Application of nanotechnology to cancer radiotherapy
Kumar Bishwajit Sutradhar, Md. Nanoparticles are rapidly being developed and trialed to overcome several limitations of traditional drug delivery systems and are coming up as a distinct therapeutics for cancer treatment. Conventional chemotherapeutics possess some serious side effects including damage of the immune system and other organs with rapidly proliferating cells due to nonspecific targeting, lack of solubility, and inability to enter the core of the tumors resulting in impaired treatment with reduced dose and with low survival rate.
International Journal of Biological Sciences. Journal of Cancer. Journal of Genomics.
Nanoparticles in Cancer Therapy: Novel Concepts, Mechanisms and Applications
Metrics details. Radiotherapy has been an integral treatment modality for cancer. The field arose from and progressed through innovations in physics, engineering, and biology. The evolution of radiation oncology will rely on the continued adoption of advances from other fields. A new area of science that possesses the ability to impact radiation oncology is nanomedicine. Materials on the nanoscale provide many unique properties such as enhanced permeability and retention effect and superparamagnetism that are well suited for applications in radiation oncology. In this review, we will provide a comprehensive summary on how nanotechnology can improve cancer radiotherapy in aspects of treatment delivery and monitoring as well as diagnosis.
Nanotechnology in Cancer Drug Delivery and Selective Targeting
Although cancer survival rates have remarkably increased over the past 50 years, those in late stage cancers remain low such as glioma, pancreatic cancer, liver cancer, breast cancer, etc. Global researchers are working hard to find cures for these cancers. Among several emerged technologies over the past two Among several emerged technologies over the past two decades e. Nanoparticles possess several advantages such as combination therapy, tumor targeting, controlled release, long circulation, reduced toxicity and concurrent live imaging. Nanoparticles, constructed from lipids, proteins, polymers e. PLGA , drug molecules or inorganic materials e.
In the last decades, nanotechnology-based tools started to draw the attention of research worldwide. They offer economic, rapid, effective, and highly specific solutions for most medical issues. As a result, the international demand of nanomaterials is expanding very rapidly. In medicine, various applications of nanotechnology proved their potential to revolutionize medical diagnosis, immunization, treatment, and even health care products. The loading substances can be coupled with a large set of nanoparticles NPs by many means: chemically conjugation , physically encapsulation , or via adsorption.
Nanotechnology Applications for Cancer Chemotherapy
Basic pathology and etiology of tumor and its microenvironment 2. EPR effect and its implication in passive targeting of nanocarrier to the tumor 3. Temperature sensitive carrier temperature directed tumor cell eradication 5.
Cancer is one of the most deadly diseases in the world. In recent years, nanotechnology, as a unique technology, has been comprehensively applied in the therapy of cancer through diagnosis, imaging and theranostics. Additionally, with the emergence of advanced biomaterials which are capable of being applied in biomedical, research in cancer nanotechnology has made significant progress. Particularly, nanomaterials with dimensions below several hundred nanometers are intensively studied among these advanced biomaterials.
Recent developments in nanotechnology have provided researchers with new tools for cancer imaging and treatment. This technology has enabled the development of nanoscale devices that can be conjugated with several functional molecules simultaneously, including tumor-specific ligands, antibodies, anticancer drugs, and imaging probes. Since these nanodevices are to 1,fold smaller than cancer cells, they can be easily transferred through leaky blood vessels and interact with targeted tumor-specific proteins both on the surface of and inside cancer cells. Therefore, their application as cancer cell-specific delivery vehicles will be a significant addition to the currently available armory for cancer therapeutics and imaging. Abstract Recent developments in nanotechnology have provided researchers with new tools for cancer imaging and treatment.
Application of nanotechnology to cancer radiotherapy
Снова последовало молчание: Стратмор размышлял о том, что она сказала. - Следопыт? - Он, похоже, был озадачен. - Следопыт вышел на Хейла.
- Кто будет охранять охранников. Иными словами - кто будет охранять Агентство национальной безопасности, пока мы охраняем мир. Это было любимое изречение, которым часто пользовался Танкадо. - И что же, - спросила Мидж, - это и есть искомый ключ.
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И снова этот голос. Он присел на корточки и в десяти метрах от себя увидел чей-то силуэт. - Мистер. Беккер узнал голос. Это девушка. Она стояла у второй входной двери, что была в некотором отдалении, прижимая сумку к груди.
Один раз Грег Хейл уже разрушил планы АНБ. Что мешает ему сделать это еще. Но Танкадо… - размышляла. - С какой стати такой параноик, как Танкадо, доверился столь ненадежному типу, как Хейл. Сьюзан понимала, что теперь это не имеет никакого значения.