Association Between Thiazide Diuretucs User And Risk Of Fracture At Elderly Age Pdf

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association between thiazide diuretucs user and risk of fracture at elderly age pdf

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Coughlan T. Coughlan, F. DOI:

The raw data supporting the conclusions of this manuscript will be made available by the authors, without undue reservation, to any qualified researcher.

Thiazide Use and Fracture Risk: An updated Bayesian Meta-Analysis

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Thiazide Use and Fracture Risk: An updated Bayesian Meta-Analysis

Metrics details. Stroke is a major risk factor for osteoporosis and fractures. No study has evaluated the association between diuretic use and risk of vertebral fracture in stroke patients, although a considerable proportion of stroke patients are prescribed diuretics for hypertension. Our study aimed to investigate whether treatment with thiazides or loop diuretics affects the risk of vertebral fracture after stroke. A population-based propensity score-matched retrospective cohort study was conducted using the Taiwan National Health Insurance Research Database.

Volume 9, Number 11, November , pages Background: An alleged association of chronic use of thiazide diuretics with an increased risk of bone fragility fractures has been highlighted by a relatively recent prospective cohort study. However, the concept that thiazides exert a beneficial effect on osteoporosis is still a predominant view. This effect would be mediated by the decrease in renal clearance of calcium ions, a pharmacological feature recognized for a long time now to this class of drugs, as opposed to the increase in calcium urinary excretion attributed instead to loop diuretics, i. The purpose of this retrospective study was to attempt to clarify whether regular use of thiazide diuretics as antihypertensive therapeutics is associated with a significantly increased risk of osteoporotic fractures in female patients aged 65 or over.

Thiazide, a first-line therapy for hypertension, lowers blood pressure, increases bone mineral density, and reduces the risk of fractures. However, hyponatremia, an adverse effect of thiazide, is associated with increased risk of osteoporosis and fractures. It is currently unclear whether thiazide-associated hyponatremia TAH outweighs the protective effects of thiazide. Those diagnosed with hyponatremia within three years after initiation of thiazide were selected for the TAH group. Thiazide users without hyponatremia were selected for the control group.

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Every second in the United States, an older adult falls, making falls the No. In fact, more than 1 in 4 older people fall each year. Falls often lead to hospitalizations, hip fractures and other significant injuries, and loss of independence leading to nursing home admission.

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  4. Quanwitaka 23.04.2021 at 01:42

    between diuretic use and risk of vertebral fracture in stroke patients, although a used to calculate hazard ratios (HRs) of vertebral fractures among patients according to thiazide or loop diuretic use 13%, including prevalence as high as 20% in people aged without salaries such as students, children, elderly, and.